Thioridazine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Thioridazine 是一种抗精神病药，用于治疗精神分裂症和精神病，具有 D4 选择性或 5-羟色胺拮抗作用。

Thioridazine is an antipsychotic drug, used in the treatment of schizophrenia and psychosis, shows D4 selectivity or serotonin antagonism.(In Vitro):Thioridazine (0.01-100 μM; 48 h) reduces the cell viability of NCI-N87 and AGS cells in a concentration-dependent manner.Thioridazine (15 μM; 24 h) reduces cell viability of the cervical (HeLa, Caski and C33A) and endometrial (HEC-1-A and KLE) cancer cells.Thioridazine (1-15 μM; 24-48 h) induces gastric cancer cell death via the mitochondrial apoptosis pathway and mitochondrial pathway.Thioridazine (15 μM; 24 h) modulates the regulation of cell cycle progression by interfering with the PI3K/Akt pathway and induces G1 cell cycle arrest in cervical and endometrial cancer cells .Thioridazine inhibits the growth of antibiotic-sensitive and multidrug-resistant strains of A. baumannii.(In Vivo):Thioridazine (25 mg/kg; i.p. every 3 days for 3 weeks) extends the survival of tumor-bearing mice and reduces the number of pluripotent embryonal carcinoma (EC) cells within tumors.Thioridazine (1.0-5.0 mg/kg; s.c.) reduces oral behavior and selectively blocks repetitive head bobbing.

Cell Proliferation Assay Cell Line:NCI-N87 and AGS cells Concentration:0.01, 0.1, 0.5, 1, 5, 10, 20, 50, 100 μM.Incubation Time:48 hours Result:Exhibited cytotoxicity in gastric cancer cells.Western Blot Analysis Cell Line:NCI-N87 and AGS cells Concentration:1, 5, 10, 15 μM Incubation Time:24, 48 hours Result:Down regulated the precursors of caspase-9, caspase-8 and caspase-3.

Animal Model:Nude and Rag2KO mice were injected with iPS cells or NT2D1 cells Dosage:25 mg/kg Administration:I.p. every 3 days for 3 weeks Result:Reduced the number of OCT4-expressing cells within malignant teratocarcinomas and extended the survival of tumor-bearing mice.With no effect on fertility.

Aldazine | Mellaril

Endocrinology/Hormones

5-HT Receptor

5-HT| Adrenergic Receptor| Dopamine| Potassium Channel

Neurological Disease

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130-61-0

407.04

C21H27ClN2S2

>98% (HPLC)

Soluble in DMSO

Cl.CSC1=CC2=C(SC3=CC=CC=C3N2CCC2CCCCN2C)C=C1

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(-20℃)

With Ice Pack

≥ 2 years